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Weight Change During the Second Year of Semaglutide UseExpand
Cosmos Study

Most Adults Without Diabetes Maintain Their GLP-1 Weight Loss Through a Second Year, Though Gradual Regain Begins After the One-Year Mark

Among adults without diabetes who lost weight during their first year on a GLP-1 medication, most sustained that loss into the second year. At the two-year mark, 53.1% of semaglutide patients and 52.9% of tirzepatide patients had maintained their weight within a narrow band of their one-year weight, and a further 31.9% (semaglutide) and 39.3% (tirzepatide) had lost even more.

Dual-Team Study|August 13, 2026
Weight Change During the Second Year of Semaglutide UseExpand
Cosmos Study

Adults with Diabetes on GLP-1s Largely Maintain Their First-Year Weight Loss

Among adults with diabetes who lost weight during their first year on a GLP-1 medication, most maintained or extended that loss when the GLP-1 was continued into the second year. At the two-year mark, 37.7% of semaglutide patients and 47.3% of tirzepatide patients had maintained their weight loss, and another 35.4% and 38.6%, respectively, had continued to lose weight.

Dual-Team Study|August 12, 2026

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