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Weight Change During the Second Year of Semaglutide UseExpand
Cosmos Study

Most Adults Without Diabetes Maintain Their GLP-1 Weight Loss Through a Second Year, Though Gradual Regain Begins After the One-Year Mark

Among adults without diabetes who lost weight during their first year on a GLP-1 medication, most sustained that loss into the second year. At the two-year mark, 53.1% of semaglutide patients and 52.9% of tirzepatide patients had maintained their weight within a narrow band of their one-year weight, and a further 31.9% (semaglutide) and 39.3% (tirzepatide) had lost even more.

Dual-Team Study|August 13, 2026

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