Epic Research

Projected Colorectal Cancer Detection Rates for Routine Screenings Starting at Age 45

Cosmos Study

Projected Colorectal Cancer Detection Rates in Adults Under Age 45

Based on colorectal cancer detection rates among more than 3 million screening-eligible adults, our model estimates that at age 40 approximately 111 cancers would be detected per 100,000 screenings, compared with 159 per 100,000 screenings at age 45, the current recommended starting age. Based on the model, this equates to nearly 44% more 40-year-olds needing to be screened to detect one colorectal cancer (CRC) case compared to the number of 45-year-olds who would need to be screened.

Dual-Team Study|June 18, 2026

Percent of Patients with New Anemia by Weight-Change Stratum at 15 Months

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Cosmos Study

Bariatric Surgery Patients Have Higher Rates of Diagnosed Nutritional Deficiencies Than GLP-1 and Other Weight-Loss Medication Patients at 15 Months

At 15 months post-treatment, 12.5% of bariatric surgery patients had a new diagnosis of nutritional or iron-deficiency anemia, compared to 4.6% of GLP-1 patients and 3.8% of patients on other weight-loss medications.

Dual-Team Study|June 11, 2026

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Cosmos Study

Fewer Antibiotics Prescribed for Patients with Viral Diagnoses Post-Pandemic

The share of outpatient encounters with a systemic antibiotic prescription fell from 10.4% pre-pandemic to 8.0% during the pandemic and partially returned to pre-pandemic levels at 9.1% post-pandemic.

Dual-Team Study|June 2, 2026

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HbA1c Change Category Three Months After Stopping GLP-1s

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Cosmos Study

Most Patients with Type 2 Diabetes Maintain HbA1c Improvements a Year After Stopping GLP-1 Medications

Three months after stopping a GLP-1, 40% of patients had further improved their HbA1c compared to when they discontinued the GLP-1, 48% kept some of their improvement, and just 12% had a worse HbA1c compared to their pre-GLP-1 level.

Dual-Team Study|May 28, 2026

Quarterly Scarlet Fever Rate for Pediatric Patients

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Cosmos Study

Scarlet Fever Rates Rose Sharply After the Pandemic and Were Associated with Higher Complication Risk Than Strep Throat Alone

Scarlet fever diagnoses among pediatric patients dropped sharply during the COVID-19 pandemic and then surged well above pre-pandemic levels, peaking around 47 per 100,000 pediatric patients who had a visit in Q1 2023 and Q1 2024, nearly double the pre-pandemic seasonal peak of 24 per 100,000 in Q1 2019. By Q1 2025, the peak was down to 18.9 per 100,000.

Dual-Team Study|May 26, 2026

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GLP-1 Use Has More Than Quadrupled Since 2021 as Obesity Rates Continue to Show Signs of Decline

Two new data trackers from Epic Research now provide quarterly snapshots of GLP-1 use and BMI distribution in the U.S. adult population.

May 21, 2026

Surgical Site Infection Likelihood After Knee Replacement

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Cosmos Study

Preoperative Weight Change Associated with Higher Likelihood of Complications After Hip and Knee Replacement

Most patients who lost weight before hip or knee replacement had a higher likelihood of surgical site infection and mechanical failure than patients in the same starting BMI class whose weight remained stable. For infection, the likelihood increased with each level of loss, reaching more than six times as likely among overweight patients who lost 20% or more before knee replacement.

Dual-Team Study|May 14, 2026

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Firearm Injury Risk Following an ED Visit Among Males by Age and Region

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Cosmos Study - Collaboration

ED Visits for Motor Vehicle Crashes Associated with Elevated Risk of Subsequent Firearm Injury for Young Male Patients

Male patients aged 10 to 15 who had an ED visit for a motor vehicle crash (MVC) were as much as four times as likely to experience a subsequent firearm injury compared with those whose ED visit was for a fall, in some parts of the United States.

Dual-Team Study|January 15, 2026

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Cosmos Study

Cardiovascular Event Risk Increases More Sharply for Men Than Women at Very Low Average Blood Pressure

The risks of myocardial infarction (MI), ischemic stroke, and hemorrhagic stroke are increased for patients with high or low average systolic blood pressure (BP). The risks are greater at very low systolic BP than at very high systolic BP.

Dual-Team Study|October 8, 2025

Proportion of Patients by Weight Change After Stopping Semaglutide

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Cosmos Study

Two Years After Stopping GLP-1s, Most Patients Sustain at Least Some Weight Loss

At 24 months post-cessation, 56% of semaglutide, 52% of liraglutide, and 55% of tirzepatide patients kept the weight off or lost additional weight.

Dual-Team Study|September 9, 2025

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Projected Colorectal Cancer Detection Rates in Adults Under Age 45

Projected Colorectal Cancer Detection Rates in Adults Under Age 45

Bariatric Surgery Patients Have Higher Rates of Diagnosed Nutritional Deficiencies Than GLP-1 and Other Weight-Loss Medication Patients at 15 Months

Fewer Antibiotics Prescribed for Patients with Viral Diagnoses Post-Pandemic

Recent Posts

Most Patients with Type 2 Diabetes Maintain HbA1c Improvements a Year After Stopping GLP-1 Medications

Most Patients with Type 2 Diabetes Maintain HbA1c Improvements a Year After Stopping GLP-1 Medications

Scarlet Fever Rates Rose Sharply After the Pandemic and Were Associated with Higher Complication Risk Than Strep Throat Alone

Scarlet Fever Rates Rose Sharply After the Pandemic and Were Associated with Higher Complication Risk Than Strep Throat Alone

GLP-1 Use Has More Than Quadrupled Since 2021 as Obesity Rates Continue to Show Signs of Decline

GLP-1 Use Has More Than Quadrupled Since 2021 as Obesity Rates Continue to Show Signs of Decline

Preoperative Weight Change Associated with Higher Likelihood of Complications After Hip and Knee Replacement

Preoperative Weight Change Associated with Higher Likelihood of Complications After Hip and Knee Replacement

Featured Posts

ED Visits for Motor Vehicle Crashes Associated with Elevated Risk of Subsequent Firearm Injury for Young Male Patients

Cardiovascular Event Risk Increases More Sharply for Men Than Women at Very Low Average Blood Pressure

Two Years After Stopping GLP-1s, Most Patients Sustain at Least Some Weight Loss

ED Visits for Motor Vehicle Crashes Associated with Elevated Risk of Subsequent Firearm Injury for Young Male Patients

Cardiovascular Event Risk Increases More Sharply for Men Than Women at Very Low Average Blood Pressure

Two Years After Stopping GLP-1s, Most Patients Sustain at Least Some Weight Loss

Short-Term Post-Op Opioids Associated with Better Early Functional Recovery After Hip Replacement, Less so for Knee Replacement

ED Visits for Motor Vehicle Crashes Associated with Elevated Risk of Subsequent Firearm Injury for Young Male Patients

Cardiovascular Event Risk Increases More Sharply for Men Than Women at Very Low Average Blood Pressure

Two Years After Stopping GLP-1s, Most Patients Sustain at Least Some Weight Loss

Don't Miss Articles

Short-Term Post-Op Opioids Associated with Better Early Functional Recovery After Hip Replacement, Less so for Knee Replacement

Low-Dose Aspirin Usage for Primary Prevention of Cardiovascular Disease Has Fallen by More Than Half Since 2018

Once-Daily Antihypertensive Dosing Associated with Better Blood Pressure Control Than Multi-Dose Regimens for Most Medication Classes

Emergency Departments Now Handle Nearly Half of RSV Encounters as Hospitalizations and ICU Admissions Decline

At-Home Nasal Flu Vaccine Associated with Lower Influenza Infection Rates Than In-Clinic Nasal Vaccine

GLP-1 Use Associated with Lower Osteoporosis Risk in Adults with Type 2 Diabetes but Higher Risk in Adults Without Diabetes

Fentanyl Testing Associated with Short-Term Survival Benefits; Increased Long-Term Mortality Risk Among Overdose Patients

Influenza Visits Peak Higher This Season, Especially Among Children and Older Adults

“Lean MASLD” Typically Clustered Near Obese BMI Threshold

Telehealth Use for Primary Care Visits Has Stabilized, with Higher Use in Metropolitan Areas and Among Non-English Speakers

Prostate Cancer Screening and Diagnosis Rates Up for 55–84-Year-Old Men

Adding or Switching Diuretics Is Associated with Fewer CHF Exacerbations Than Increasing Dose or Frequency