Epic Research

Weight Change During the Second Year of Semaglutide Use

Cosmos Study

Most Adults Without Diabetes Maintain Their GLP-1 Weight Loss Through a Second Year, Though Gradual Regain Begins After the One-Year Mark

Among adults without diabetes who lost weight during their first year on a GLP-1 medication, most sustained that loss into the second year. At the two-year mark, 53.1% of semaglutide patients and 52.9% of tirzepatide patients had maintained their weight within a narrow band of their one-year weight, and a further 31.9% (semaglutide) and 39.3% (tirzepatide) had lost even more.

Dual-Team Study|August 13, 2026

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Cosmos Study

Adults with Diabetes on GLP-1s Largely Maintain Their First-Year Weight Loss

Among adults with diabetes who lost weight during their first year on a GLP-1 medication, most maintained or extended that loss when the GLP-1 was continued into the second year. At the two-year mark, 37.7% of semaglutide patients and 47.3% of tirzepatide patients had maintained their weight loss, and another 35.4% and 38.6%, respectively, had continued to lose weight.

Dual-Team Study|August 12, 2026

Newly Diagnosed Parkinson's Patients by Age Group

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Cosmos Study

Most Parkinson's Diagnoses Occur After Age 70, with a Slight Rise in Diagnosis Age Since 2017

Among patients newly diagnosed with Parkinson’s disease, 90.2% were aged 60 or older at diagnosis, with a median diagnosis age of 73. Diagnoses before age 50 were rare, accounting for 2.6% of patients.

Dual-Team Study|August 6, 2026

Recent Posts

Treatment Eligibility Under the 2018 and 2026 Hyperlipidemia Guidelines

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Cosmos Study

New 2026 Hyperlipidemia Guideline Expand Treatment Eligibility from 41% to 55% of Adults

Under the 2026 cholesterol treatment guideline, 54.6% of adults aged 20–79 without established cardiovascular disease were eligible for lipid-lowering therapy, compared with 41.3% under the 2018 guideline, a 13.3 percentage-point increase in the treatment-eligible share.

Dual-Team Study|August 5, 2026

Hormone Therapy Use Rate Over Time by Age Group

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Cosmos Study

Hormone Therapy Use Nearly Doubled Since 2017, Led by Women in Their Late 40s and Early 50s

Among women seen in outpatient care, the rate of hormone therapy (HT) use rose from 1.7% in January 2017 to 3.6% in April 2026, a near-doubling. The increase was modest through 2022 and then accelerated sharply from 2023 onward.

Dual-Team Study|July 30, 2026

Testosterone Prescription Prevalence Over Time by Age Group

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Cosmos Study

After Nearly a Decade-Long Decrease, Testosterone Prescribing Rates Rising Again

The share of male patients prescribed testosterone fell from 0.83% in 2013 to 0.64% by 2021. It then rose to 0.93% in 2025 and reached 0.95% in the partial first half of 2026.

July 29, 2026

Likelihood of On-Time Cancer Screening by Presence of Autism Diagnosis

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Cosmos Study

Patients Diagnosed with Autism Are Less Likely to Receive On-Time Cancer Screening, Except for Colorectal Cancer

Among patients newly eligible for cancer screening, those diagnosed with autism had a 35.6% lower likelihood of on-time screening overall compared to patients without autism. The gap was largest for cervical (50.7% lower likelihood) and breast (28.7% lower likelihood) cancer screening, and smaller but still significant for prostate cancer screening (14.9% lower likelihood).

Dual-Team Study|July 28, 2026

Featured Posts

Firearm Injury Risk Following an ED Visit Among Males by Age and Region

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Cosmos Study - Collaboration

ED Visits for Motor Vehicle Crashes Associated with Elevated Risk of Subsequent Firearm Injury for Young Male Patients

Male patients aged 10 to 15 who had an ED visit for a motor vehicle crash (MVC) were as much as four times as likely to experience a subsequent firearm injury compared with those whose ED visit was for a fall, in some parts of the United States.

Dual-Team Study|January 15, 2026

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Cosmos Study

Cardiovascular Event Risk Increases More Sharply for Men Than Women at Very Low Average Blood Pressure

The risks of myocardial infarction (MI), ischemic stroke, and hemorrhagic stroke are increased for patients with high or low average systolic blood pressure (BP). The risks are greater at very low systolic BP than at very high systolic BP.

Dual-Team Study|October 8, 2025

Proportion of Patients by Weight Change After Stopping Semaglutide

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Cosmos Study

Two Years After Stopping GLP-1s, Most Patients Sustain at Least Some Weight Loss

At 24 months post-cessation, 56% of semaglutide, 52% of liraglutide, and 55% of tirzepatide patients kept the weight off or lost additional weight.

Dual-Team Study|September 9, 2025

See All Epic Research Articles →

Most Adults Without Diabetes Maintain Their GLP-1 Weight Loss Through a Second Year, Though Gradual Regain Begins After the One-Year Mark

Most Adults Without Diabetes Maintain Their GLP-1 Weight Loss Through a Second Year, Though Gradual Regain Begins After the One-Year Mark

Adults with Diabetes on GLP-1s Largely Maintain Their First-Year Weight Loss

Most Parkinson's Diagnoses Occur After Age 70, with a Slight Rise in Diagnosis Age Since 2017

Recent Posts

New 2026 Hyperlipidemia Guideline Expand Treatment Eligibility from 41% to 55% of Adults

New 2026 Hyperlipidemia Guideline Expand Treatment Eligibility from 41% to 55% of Adults

Hormone Therapy Use Nearly Doubled Since 2017, Led by Women in Their Late 40s and Early 50s

Hormone Therapy Use Nearly Doubled Since 2017, Led by Women in Their Late 40s and Early 50s

After Nearly a Decade-Long Decrease, Testosterone Prescribing Rates Rising Again

After Nearly a Decade-Long Decrease, Testosterone Prescribing Rates Rising Again

Patients Diagnosed with Autism Are Less Likely to Receive On-Time Cancer Screening, Except for Colorectal Cancer

Patients Diagnosed with Autism Are Less Likely to Receive On-Time Cancer Screening, Except for Colorectal Cancer

Featured Posts

ED Visits for Motor Vehicle Crashes Associated with Elevated Risk of Subsequent Firearm Injury for Young Male Patients

Cardiovascular Event Risk Increases More Sharply for Men Than Women at Very Low Average Blood Pressure

Two Years After Stopping GLP-1s, Most Patients Sustain at Least Some Weight Loss

ED Visits for Motor Vehicle Crashes Associated with Elevated Risk of Subsequent Firearm Injury for Young Male Patients

Cardiovascular Event Risk Increases More Sharply for Men Than Women at Very Low Average Blood Pressure

Two Years After Stopping GLP-1s, Most Patients Sustain at Least Some Weight Loss

COVID-19 Activity Falls to Post-Pandemic Low; Test Positivity Showing Signs of Rebound

ED Visits for Motor Vehicle Crashes Associated with Elevated Risk of Subsequent Firearm Injury for Young Male Patients

Cardiovascular Event Risk Increases More Sharply for Men Than Women at Very Low Average Blood Pressure

Two Years After Stopping GLP-1s, Most Patients Sustain at Least Some Weight Loss

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GLP-1 Treatment Associated with a 39% Lower Risk of Repeat Substance Overdose

2025 Hypertension Guideline Update Modestly Expands Stage 1 Treatment Eligibility, with Net Increases Concentrated Among Older and Female Patients

Gambling Disorder Diagnoses Have Risen More Than 60% in States That Legalized Sports Betting

Projected Colorectal Cancer Detection Rates in Adults Under Age 45

Bariatric Surgery Patients Have Higher Rates of Diagnosed Nutritional Deficiencies Than GLP-1 and Other Weight-Loss Medication Patients at 15 Months

Fewer Antibiotics Prescribed for Patients with Viral Diagnoses Post-Pandemic

Most Patients with Type 2 Diabetes Maintain HbA1c Improvements a Year After Stopping GLP-1 Medications

Scarlet Fever Rates Rose Sharply After the Pandemic and Were Associated with Higher Complication Risk Than Strep Throat Alone

GLP-1 Use Has More Than Quadrupled Since 2021 as Obesity Rates Continue to Show Signs of Decline