One-third of suzetrigine prescriptions (33.0%) were written in encounters with a diagnosis of chronic pain, compared with 6.7% of opioid prescriptions. Opioids were most often prescribed during encounters with evidence of surgery (48.8%) and acute pain (19.8%) compared to 10.2% and 31.8%, respectively, for suzetrigine.

Among adults who have had a documented substance overdose, those who started on a GLP-1 had a 39% lower risk of a repeat overdose within three years of their overdose compared to patients who were never prescribed a GLP-1. Patients who started and later discontinued a GLP-1 still had a 20% lower risk than patients who never used a GLP-1.

Among adults aged 40–79 with stage 1 hypertension, treatment eligibility rose modestly from 45.2% under the 2017 guideline to 47.0% under the 2025 guideline. Overall, 3.2% of patients would be treated differently under the new guideline (2.5% gained eligibility, 0.7% lost eligibility).

Among adult patients living in states that have legalized sports betting, the quarterly rate of diagnosed gambling disorder rose from 3.0 per 100,000 patients in Q1 2018 to 4.8 per 100,000 in Q1 2026, around a 61% increase.