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Cosmos Study

Firstborn Children and Only Children More Likely to Have Anxiety and Depression Than Later-Born Children

October 15, 2024
Dual-Team Study
Team A:Blaine Franklin, DPT, PTEmily Higgs
Team B:Kersten Bartelt, RNNeil Sandberg

Key Findings

  • Firstborn children who have siblings are 48% more likely to have anxiety and 35% more likely to have depression compared to children who are born second or later. 
  • Only children are 42% more likely to have anxiety and 38% more likely to have depression compared to children who are born second or later. 

There are various factors that are known to affect the likelihood of childhood mental health conditions. These factors include premature birth, sex, BMI, maternal history of mental health disorders, and trauma.1,2 However, there is little research on the effect of birth order on the likelihood of childhood anxiety and depression. Understanding this could aid in identifying additional risk factors for mental health disorders. 

We studied 182,477 children born between 2009 and 2016 who had a well-child visit during their eighth year of life, as this is when the U.S. Preventive Services Task Force suggests beginning anxiety screening.3 We adjusted for patient age, sex, race, ethnicity, history of other mental health disorders, mother’s history of anxiety or depression, insurance coverage type, premature birth, Social Vulnerability Index quintile, Rural Urban Commuting Area classification, and BMI. 

Children born first who have siblings had a 48% greater likelihood of being diagnosed with anxiety by their eight-year well-child visit compared to children who were born second or later, as seen in Figure 1. Similarly, only children had a 42% greater likelihood of anxiety than children born second or later. 

Figure 1
Likelihood of Anxiety by Birth Order
Likelihood of Anxiety by Birth Order
Figure 1. Likelihood of anxiety by birth order.

The likelihood of depression is higher for both firstborn children with siblings and only children, as seen in Figure 2. Firstborn children were 35% more likely to be diagnosed with depression compared to those who were born second or later, while only children were 38% more likely. 

Figure 2
Likelihood of Depression by Birth Order
Likelihood of Depression by Birth Order
Figure 2. Likelihood of depression by birth order.

Original Publication Date: October 15, 2024
Last Updated: October 22, 2024


These data come from Cosmos, a dataset created in collaboration with a community of Epic health systems representing more than 274 million patient records from 1,500 hospitals and more than 36,000 clinics from all 50 states, Lebanon, and Saudi Arabia. This study was completed by two teams that worked independently, each composed of a clinician and research scientists. The two teams came to similar conclusions. Graphics by Brian Olson. 

References

  1. Kowalchuk A, Gonzalez SJ, Zoorob RJ. Anxiety disorders in children and adolescents. Am Fam Physician. 2022;106(6):657-664. https://www.aafp.org/pubs/afp/issues/2022/1200/anxiety-disorders-children-adolescents.html. Accessed September 3, 2024. 
  2. Moore PS, Mokrova I, Frazier JA, et al. Anxiety and depression correlates at age 10 in children born extremely preterm. J Pediatr Psychol. 2021;46(4):422-432. doi:10.1093/jpepsy/jsaa118 
  3. Anxiety in children and adolescents: Screening. U.S. Preventive Services Task Force. Published October 11, 2022. https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/screening-anxiety-children-adolescents. Accessed September 30, 2024.